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Cell-based calcium flux assays are widely used in high throughput screening (HTS) to determine agonist-stimulated and antagonist-inhibited signaling through G protein-coupled receptors (GPCRs), a large family of integral membrane proteins and an important target classs in drug discovery. Accurate measurements of intracellular calcium concentration and mobilization allows for a more comprehensive understanding of calcium regulated signaling pathways, cellular functions and pathological processees.
Intracellular pH, the activity of free protons (H+) within a cell, is one of the most important aspects of the intracellular environment. Changes of intracellular pH are implicated in diverse physiological and pathological processes, including cell proliferation, apoptosis, fertilization, malignancy, multidrug resistance, ion transport, lysosomal storage disorders and Alzheimer's disease.
The Screen Quest™ product series includes a variety of biological research materials for multiple applications. The series includes assay kits pertaining to multiple cellular activities, lab-engineered receptor-coupled cells and chimeric cell lines, and even optimized assay buffers. This wide range is reflective of an in-house optimization process that showcases careful component selection along with extensive quality testing.
G-Protein Coupled Receptors (GPCRs) are known as seven transmembrane spanning receptors or metabotropic receptors. They are the largest family of membrane receptors in the entire human genome. As the name suggests, it functions by coupling itself with G-protein to regulate intracellular signalling pathways. G-proteins possess GTPase activity and controls the function of these receptors. The structure of GPCRs consists of a single polypeptide chain comprising of seven transmembrane helices, where N-terminal domain is extracellular and C-terminal is located intracellularly.
Nicotinamide adenine dinucleotides are abundant soluble cofactors that undergo reversible oxidation and reduction in major metabolic pathways. In cells they are present in oxidized and reduced states as their unphosphorylated (NAD and NADH) and phosphorylated (NADP and NADPH) forms. These dinucleotides work in pairs, and each pair has distinct functions. They have become a point of focus in cancer research because, as metabolites, they can tie metabolic pathways to transcriptional control, epigenetics and cell signaling as cells switch from a normal metabolism to a cancer cell (proliferative) metabolism.
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