Copure C8/SAX is composed of silica gel bonded with octyl and quaternary ammonium groups at a specific ratio. It’s a mixed-mode sorbent with two retention mechanisms: octyl groups provide moderately hydrophobic interactions, quaternary ammonium groups provide strong anion exchange.
C8/SAX will be a better choice if very strong absorption in C18, C8 or SAX packing results in difficult elution of some analytes.