Copure C8/SCX is composed of silica gel bonded with octyl and phenylsulfonic acid groups at a specific ratio. It’s a mixed-mode sorbent with two retention mechanisms: octyl groups provide moderately hydrophobic interactions, phenylsulfonic acid groups provide strong cation exchange
C8/SCX will be a better choice if very strong absorption in C18, C8 or SCX packing results in difficult elution of some analytes.
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